Tuesday, August 08, 2017

Medical: At the all-you can eat Pharma Buffet


Via Pill in the minutes before Chemo Starts
Tylenol - to head off flu side effects today and the blood vessel inflammation*
Benadryl - as antihistamine (also anti-inflammation)
Fenadine - generic Allegra, also as antihistamine / anti-allergy
Zofran - Anti nausea

Via Intervenous Today
Steriods - a steroidal anti-inflammatory, also to fight the inflammation of either Ritxan or Benda.
Rituxan - the antibodies to turn my immune system on its own B-cells (today)
Bendamustine - (half dose) The(mild) poison that attacks fast-dividing cells

Later today via pill (and for the next year)
Acyclovir - an anti-viral, to prevent the suppression of my immune system from allowing old Chicken Pox to re-emerge as Shingles

Tomorrow
Bendamustine - Second half dose, injected into a different vein to limit irritation.

The idea is that my cancers is the only tissue that is attacked by both chemicals they are giving me.

Rituxan 

  • causes all CD20+ B cells to be attacked by other immune cells
  • which is a good chunk of my immune system
  • hence the side effects of allergic reactions and vulnerability to cold/flu/etc

Benda 

  • a chemical attack all fast-dividing cells 
  • like the lining of my throat and gut (but mostly spares hair follicles, somehow)
  • hence the side effects of nausea (if the gut can't take it) and irritation anywhere it goes

Right now, I dread the Zofran because "anti-nausea" easily transforms into "pro-constipation"



* I was excited to learn that any chemo drug with "must" in its name, such as tomorrow's Bendamustine, is a derivative of WWI Mustard Gas, which, you'll recall Great Uncle Duffield Swan was hit with in the Great War.  Mustards are blistering agents, so yeah, inflammation, particularly of the blood vessels at the point of infusion, is a known side effect.

I've been calendared for a port in my chest, implanted under the skin, that will deliver September's chemo straight to a big vein (more dilute) so as to lessen inflammation.

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