Let's look again at this blood-lymph family tree:
Right now, inside you, there's a constantly-renewing stream of all the cells on this family tree. The cells on the right have specific functions and specific life spans, but generally the cells on the right are replaced every week or two by new cells made in the marrow and migrating out into the blood and lymph systems. The whole process in a normal person is driven by the fast division of the stem cells at the left, and their migration out to replace dying cells in the right column.
At some point in early 2017, the B cells that worked as my Lymph's Mantle Cells went rogue, and, instead of dying normally and waiting to be replaced by cells migrating out of my marrow, started reproducing themselves in situ in my neck and colon. My Mantle Cell Lymphoma was the result of the fast division of the B Cells at lower right.
My old system had two types of fast dividing cells, on both left and right, when it should have only had fast dividing cells on the left.
Right now, I have two overlapping blood-lymph families living inside me.
- Old System, of which only the non-cancerous "rightmost" remain
- Reboot System of which only the presumed-cancer-free "leftmost" have been spawned yet
The purpose of the chemo last week was to kill off the very last cancerous B-Cells of the Old System but as a side-effect, ended up killing off all the "fast dividing" portions of my marrow (the left 3 columns). So, as far as the Old System goes:
- my right-column B-Cell cancer is dead by design
- my left-columns progenitor cells were killed as a side effect
- my right-column siblings of my cancer will soon die of old age and not be replaced
My current-and-upcoming nadir will happen because the last of the old system's cells will die of old age before they have a chance to be replaced by the new system.
Did that make sense?
My nadir will end when the Reboot cells have gotten numerous enough to repopulate my marrow and mature enough to be right-column cells (and start apprearing in my bloodstream).
Did that make sense?
My nadir will end when the Reboot cells have gotten numerous enough to repopulate my marrow and mature enough to be right-column cells (and start apprearing in my bloodstream).
1 comment:
Could not have been explained more coherently for a non-medical person. Thanks again for making something incredibly productive from your tough journey, and sharing it.
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