I have drawn a lot of comfort from knowledge I gained at past evenings attending Harvard Science in the News (SITN) program, where doctoral candidates describe what they're working on in ways that the public can understand.
Here is an article I am reading from the science in the news blog:
http://sitn.hms.harvard.edu/flash/2017/cancer-immunotherapy-fighting-fire-fire/
Some readers know that Matt Cam'n is in a clinical trial where CAR-T is being tested on his hard lung tumor. The article above links to this one on why that poses an extra challenge for immune therapy.(hard tumors are big, have relatively poor surface area, and create a local environment hostile to immune cells (t-cells).
http://www.genengnews.com/gen-articles/supplement-treating-solid-tumors-with-car-t-cells/5912
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These Nordic people seem to be out front of some of this. http://www.bloodjournal.org/content/112/7/2687.full?sso-checked=true
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